2022: weight change over 72 weeks
This phase 3 randomised trial enrolled 2,539 adults with obesity, or overweight plus a weight-related condition, and excluded diabetes. At 72 weeks, average body-weight change ranged from minus 15.0% to minus 20.9% across tirzepatide groups, compared with minus 3.1% with placebo. These results belong to the trial medicine and its clinical setting.
Jastreboff et al., New England Journal of Medicine (2022): Tirzepatide once weekly for the treatment of obesity